Single cell analysis enables meaningful discoveries
Bulk sequencing averages readouts, missing critical details driving complex biology.
Single cell sequencing allows scientists to see the unique gene expression patterns of each cell. This view more fully characterizes tissue heterogeneity, revealing the rare cell types that have big consequences in health and disease.
The Chromium Advantage
- >40% higher gene sensitivity and up to 60% more sample recovery compared to alternative methods.
- Enhanced detection of challenging cell types, including neutrophils.
- Reduce hands-on time and lower the risk of errors with instrument-supported automation of the most critical workflow steps.
- Produce higher quality libraries that can sequenced at lower depths.
- Backed by 10 years, over 2,200 patents, and >$1.5B in R&D investment.
Access more sample types
Profile fresh, frozen, or fixed samples—even FFPE—with optimized protocols for proven performance
Automate critical steps to reduce error
Produce up to 2.56M barcoded partitions in just minutes, with up to 80% cell recovery
Construct high-quality sequence-ready libraries
Generate libraries with up to 95% usable reads, letting you detect more genes at lower sequencing costs
Analyze & discover with ease
Process and visualize your data with powerful software tools—no bioinformatics experiences required
Universal Gene Expression
Species agnostic. Maximum versatility.
Reverse transcription-based chemistry
Delivers broadest set of information, including isoforms, SNPs, etc.
Multiomic readouts from the same cell
3' or 5' gene expression
TCR/BCR
Protein
CRISPR
For cost-effective studies
Up to 160,000 cells (1-8 samples) per run
Flex Gene Expression
Fix, batch, and run on your schedule.
Probe-based chemistry
Performs well with low-quality and FFPE samples
Multiomic readouts from the same cell
Gene expression
Protein
CRISPR
Highest throughput option
Up to 2.56M cells (1-16 samples) per run
Products
Epi Chromatin
Unmask epigenomic profiles.
ATAC-seq chemistry
Explore open chromatin regions
Link directly to 3' gene expression (Multiome kit)
Multiomic readouts from the same cell
Chromatin accessibility
3' gene expression
Scalable nuclei preparation
Profile up to 80,000 nuclei (1-8 samples) per run
Products
David Michonneau, PhD
Professor of Hematology at Saint-Louis Hospital
Gene expression
Characterize the unique transcriptomic profiles of each cell in your sample
CRISPR screening
Directly link CRISPR guide RNAs to the resulting perturbed phenotypes
Practical considerations and best practices for getting started
平台 |  Chromium单细胞分析 |  Visium空间分析 |  Xenium原位分析 |
|---|---|---|---|
何时使用 | Comprehensive single cell data 适用于细胞群体和状态的深度表征 | High-resolution spatial gene expression 了解复杂组织、邻域和细胞间相互作用。与其他空间多组学、组织学和形态学方法整合。 | |
为何使用 | 无偏的单细胞发现 每个基因的灵敏度高 | 无偏的空间发现 | 靶向的空间探索 每个基因的灵敏度高 |
应用 | 全转录组基因表达 蛋白质 TCR、BCR CRISPR ATAC | 全转录组基因表达 | 靶向基因表达（多达5 000个基因） |
分辨率 | 单细胞 | 分配在2-µm区域内的转录本 | 单细胞 |
数据读出 | 基于NGS | 基于NGS | 基于成像 |
样本兼容性 | 来自新鲜、冷冻或FFPE样本的单细胞或单细胞核悬液 | FFPE样本 | 新鲜冷冻样本 FFPE样本 |