- Explore your tissue with 5,000 genes to deeply characterize cell types, pathways, cell-cell interactions & more
- Get greater confidence in your results with an optimized assay, multimodal cell segmentation & high spatial fidelity
- Obtain results faster with up to 472 mm² of tissue analyzed in 6 days or less
Curated & validated biological content
Get started quickly with ready-to-use panels targeting major cell types and states.
Xenium Prime 5K Human Pan Tissue & Pathways Panel
Map human biological pathways, receptor–ligand pairs, cell–cell interactions, biomarkers, and more.
Xenium Prime 5K Mouse Pan Tissue & Pathways Panel
Profile murine biological pathways, receptor-ligand pairs, cell-cell interactions, biomarkers, and more.
Human Immuno-Oncology
Includes gene markers for major immune cell types, checkpoint markers, etc.
Human Multi-Tissue and Cancer
Includes gene markers for breast, colon, heart, kidney, liver, lung, pancreas, etc.
Human Breast
Breast glandular cells, epithelial cells, adipocytes, tumor, etc.
Mouse Brain
Astrocytes, interneurons, microglia oligodendrocytes, etc.
Human Brain
Astrocytes, microglia, glioblastoma, Alzheimer's disease, Parkinson's disease, etc.
Human Lung
Alveolar type 1 & 2, ciliated cells, endothelial cells, COVID-19, etc.
Mouse Tissue Atlassing
Includes gene markers for bladder, bone marrow, brain, heart, kidney, limb muscle, lung, pancreas, thymus, etc.
Human Skin
Keratinocytes, melanocytes, vascular endothelial, immune cells, melanoma, etc.
Human Colon
Absorptive enterocytes, enteroendocrine cells, goblet cells, paneth cells, fibroblasts, etc.
Complete flexibility for your research
Target unique gene markers, expression signatures, and cell types. Advanced customization allows for probes designed to target isoforms, gene fusions, and more.
01
Start a custom panel design using the Custom Panel Designer
Add up to 100 genes to a pre-designed panel or build a 480-gene standalone custom panel.
02
Review and finalize panel design recommendations
Review and address our feedback on your panel design to optimize your assay performance.
03
Order and receive panels
Work with your sales representative to order your panels.
04
Experience the power of Xenium In Situ
Explore spatially resolved single cell gene expression maps on the Xenium Analyzer.
Which option is right for you?
Panel Type | Pre-designed Panels | Add-on Custom Panels | Standalone Custom Panels |
|---|---|---|---|
Use case | Pilot experiments or projects targeting cell types and states relevant to specific tissues or applications | Supplement pre-designed panels with additional markers important for your research | Recommended when gene expression signatures differ from content in the pre-designed panels |
Number of genes | Depends on the selected panel | Up to 100 genes not covered by pre-designed panel | Up to 480 genes |
Compatible organism | Human, mouse | Human, mouse | Diploid eukaryotic species, xenografts and most species with well-annotated transcriptomes |
Turnaround time | Available for immediate shipping | 4-6 weeks including design, building, and shipping | 4-6 weeks including design, building, and shipping |
Advanced customization | Include application-specific probes to target isoforms, gene fusions, viral or bacterial sequences, protein tags, and fluorescent reporters | Include application-specific probes to target isoforms, gene fusions, viral or bacterial sequences, protein tags, and fluorescent reporters |
Frequently asked questions
The majority of RNA species are detectable since this is a probe-based assay and does not use 3’ poly(A) capture. In the future, Xenium will have the capacity to analyze thousands of targets.
Several panel options are available to help you target genes of interest. Our Pre-designed Panels, which can be customized with up to 100 genes using a Custom Add-on Panel, are available for several human and mouse tissues. You also have the option to request a Standalone Custom Panel of up to 300 genes for mammalian or most other species with well-annotated transcriptomes.
Both the add-on and standalone custom panels can include advanced custom designs for targeting isoforms, gene fusions, viral or bacterial sequences, protein tags, fluorescent reporters, and transgenes. To learn more about the custom panels for species currently not offered by 10x Genomics and advanced customization options, please refer to the following Tech Note.
Xenium panels consist of a unified assay compatible with both fresh frozen and FFPE tissue. Furthermore, the gentle chemistry utilized allows for tissues to be processed for H&E or IF staining post-Xenium processing.
Xenium is a non-destructive analysis and the same tissue sections analyzed with Xenium can be transferred off-instrument and stained for H&E or IF imaging.
The Xenium assay can take as few as 2 days with 4–6hrs of hands on time before loading on the Xenium Analyzer.
Yes, you can add up to 100 custom targets to each off-the-shelf panel. Standalone custom panels of up to 480 genes can also be designed for mammalian and most other species with well-annotated genomes.
Additionally, advanced customization probes designed for special applications (e.g. isoforms, gene fusions, viral or bacterial sequences, protein tags, fluorescent reporters, and transgenes) can be requested for both Add-on Custom and Standalone Custom Panels.
See what Xenium users are saying
Xenium In Situ Platform
Building on our years of innovation in single cell and spatial technologies, Xenium was designed to transform the way researchers can characterize RNA, protein, and cells in their native tissue environment.