Targeted Gene Expression technology focuses on a selected panel of relevant targeted genes which are directly enriched from a Visium Spatial Gene Expression library prior to sequencing. Specific enrichment of the targeted molecules of interest by hybridization-capture enables Targeted Gene Expression to provide enhanced information about the expression of targeted genes at significantly lower sequencing depths. Targeted Gene Expression is fully compatible with Visium and relies on the same underlying Space Ranger analysis software as untargeted spatial gene expresion.