The Chromium X Series offers a highly optimized approach to single cell studies and enables both low and high throughput experiments. All 10x Genomics single cell dual index assays are supported on Chromium X Series instruments. This Technical Note compares data generated from Chromium Next GEM Single Cell 3’, 5’, ATAC, and Multiome ATAC + Gene Expression assays run on both the Chromium Controller and Chromium X.